[10] Oklahoma State 21-24 Iowa State [46] 2021-10-23 19:30
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Mike Gundy
Head to Head
| NCAAF | 2020/10/24 19:30 | Iowa State v Oklahoma State | W | 21-24 |
| NCAAF | 2019/10/26 19:30 | Oklahoma State v Iowa State | W | 34-27 |
| NCAAF | 2018/10/06 19:30 | Iowa State v Oklahoma State | L | 48-42 |
| NCAAF | 2017/11/11 17:00 | Oklahoma State v Iowa State | W | 49-42 |
| NCAAF | 2016/10/08 19:30 | Iowa State v Oklahoma State | W | 31-38 |
| NCAAF | 2015/11/14 20:30 | Iowa State v Oklahoma State | W | 31-35 |
| NCAAF | 2014/10/04 16:00 | Oklahoma State v Iowa State | W | 37-20 |
| NCAAF | 2012/10/20 12:00 | Oklahoma State v Iowa State | W | 31-10 |
Home History
| NCAAF | 2021/10/16 16:00 | Oklahoma State v Texas | W | 32-24 |
| NCAAF | 2021/10/02 23:00 | Baylor v Oklahoma State | W | 14-24 |
| NCAAF | 2021/09/25 23:00 | Kansas State v Oklahoma State | W | 20-31 |
| NCAAF | 2021/09/19 01:00 | Oklahoma State v Boise State | W | 21-20 |
| NCAAF | 2021/09/11 16:00 | Tulsa v Oklahoma State | W | 23-28 |
| NCAAF | 2021/09/04 23:00 | Missouri St v Oklahoma State | W | 16-23 |
| NCAAF | 2020/12/29 22:30 | Oklahoma State v Miami Florida | W | 37-34 |
| NCAAF | 2020/12/12 20:30 | Oklahoma State v Baylor | W | 42-3 |
Away History
| NCAAF | 2021/10/16 23:30 | Iowa State v Kansas State | W | 33-20 |
| NCAAF | 2021/10/02 23:00 | Kansas v Iowa State | W | 7-59 |
| NCAAF | 2021/09/25 19:30 | Iowa State v Baylor | L | 29-31 |
| NCAAF | 2021/09/19 02:30 | Iowa State v UNLV | W | 48-3 |
| NCAAF | 2021/09/11 20:30 | Iowa v Iowa State | L | 27-17 |
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | W | 10-16 |
| NCAAF | 2021/01/02 21:00 | Oregon v Iowa State | W | 17-34 |
| NCAAF | 2020/12/19 17:00 | Oklahoma v Iowa State | L | 27-21 |
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