[33] Iowa State 31-38 West Virginia [83] 2021-10-30 18:00
Stadium: Mountaineer Field at Milan Puskar Stadium Round: 1
Home Manager: Neal Brown Away Manager: Matt Campbell
Head to Head
| NCAAF | 2020/12/05 20:30 | West Virginia v Iowa State | W | 6-42 |
| NCAAF | 2019/10/12 20:00 | Iowa State v West Virginia | W | 38-14 |
| NCAAF | 2018/10/13 23:00 | West Virginia v Iowa State | W | 14-30 |
| NCAAF | 2017/11/04 19:30 | Iowa State v West Virginia | L | 16-20 |
| NCAAF | 2016/11/26 20:30 | West Virginia v Iowa State | L | 49-19 |
| NCAAF | 2015/11/28 17:00 | West Virginia v Iowa State | L | 30-6 |
| NCAAF | 2014/11/29 17:00 | Iowa State v West Virginia | L | 24-37 |
| NCAAF | 2012/11/23 12:00 | Iowa State v West Virginia | L | 24-31 |
Home History
| NCAAF | 2021/10/23 19:30 | Oklahoma State v Iowa State | W | 21-24 |
| NCAAF | 2021/10/16 23:30 | Iowa State v Kansas State | W | 33-20 |
| NCAAF | 2021/10/02 23:00 | Kansas v Iowa State | W | 7-59 |
| NCAAF | 2021/09/25 19:30 | Iowa State v Baylor | L | 29-31 |
| NCAAF | 2021/09/19 02:30 | Iowa State v UNLV | W | 48-3 |
| NCAAF | 2021/09/11 20:30 | Iowa v Iowa State | L | 27-17 |
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | W | 10-16 |
| NCAAF | 2021/01/02 21:00 | Oregon v Iowa State | W | 17-34 |
Away History
| NCAAF | 2021/10/23 23:30 | West Virginia v TCU | W | 29-17 |
| NCAAF | 2021/10/09 16:00 | West Virginia v Baylor | L | 20-45 |
| NCAAF | 2021/10/02 19:30 | Texas Tech v West Virginia | L | 23-20 |
| NCAAF | 2021/09/25 23:30 | West Virginia v Oklahoma | L | 13-16 |
| NCAAF | 2021/09/18 16:00 | Virginia Tech v West Virginia | W | 21-27 |
| NCAAF | 2021/09/11 21:00 | LIU Brooklyn v West Virginia | W | 0-66 |
| NCAAF | 2021/09/04 19:30 | West Virginia v Maryland | L | 24-30 |
| NCAAF | 2020/12/31 21:00 | West Virginia v Army | W | 24-21 |
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