[8] Ohio 10-43 Iowa State [8] 2022-09-17 18:00
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Tim Albin
Head to Head
| NCAAF | 2003/09/06 12:00 | Iowa State v Ohio | L | 48-20 |
| NCAAF | 2001/09/22 12:00 | Ohio v Iowa State | L | 28-31 |
| NCAAF | 2000/09/02 12:00 | Iowa State v Ohio | L | 25-15 |
Home History
| NCAAF | 2022/09/10 16:00 | Ohio v Penn State | L | 10-46 |
| NCAAF | 2022/09/03 22:00 | Florida Atlantic v Ohio | W | 38-41 |
| NCAAF | 2021/11/26 17:00 | Ohio v Bowling Green | L | 10-21 |
| NCAAF | 2021/11/17 00:00 | Toledo v Ohio | L | 35-23 |
| NCAAF | 2021/11/10 01:00 | Ohio v Eastern Michigan | W | 34-26 |
| NCAAF | 2021/11/02 23:30 | Miami Ohio v Ohio | W | 33-35 |
| NCAAF | 2021/10/23 17:00 | Kent State v Ohio | L | 34-27 |
| NCAAF | 2021/10/16 16:00 | Ohio v Buffalo | L | 26-27 |
Away History
| NCAAF | 2022/09/10 20:00 | Iowa State v Iowa | W | 10-7 |
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Iowa State | W | 10-42 |
| NCAAF - Bowl Games | 2021/12/29 22:45 | Iowa State v Clemson | L | 13-20 |
| NCAAF | 2021/11/26 21:30 | TCU v Iowa State | W | 14-48 |
| NCAAF | 2021/11/20 17:00 | Iowa State v Oklahoma | L | 21-28 |
| NCAAF | 2021/11/13 20:30 | Iowa State v Texas Tech | L | 38-41 |
| NCAAF | 2021/11/06 23:30 | Texas v Iowa State | W | 7-30 |
| NCAAF | 2021/10/30 18:00 | Iowa State v West Virginia | L | 31-38 |
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