[16] Tranmere 0-1 Leyton Orient [18] 2020-10-20 18:00
Stadium: Prenton Park Round: 7
Referee: Samuel Barrott Home Manager: Michael Jackson Away Manager: Ross Embleton
Head to Head
| Anglicko - National League | 2018/02/10 15:00 | Leyton Orient v Tranmere | D | 1-1 |
| Anglicko - National League | 2017/10/04 18:45 | Tranmere v Leyton Orient | W | 2-1 |
Home History
| Anglicko - League 2 | 2020/10/17 14:00 | Newport County v Tranmere | L | 1-0 |
| Anglicko - League 2 | 2020/10/10 14:00 | Salford City v Tranmere | D | 2-2 |
| Anglicko - League 2 | 2020/10/03 14:00 | Tranmere v Scunthorpe | W | 2-0 |
| Anglicko - EFL Trophy | 2020/09/29 18:00 | Tranmere v Liverpool U21 | W | 3-2 |
| Anglicko - League 2 | 2020/09/26 14:00 | Cambridge Utd v Tranmere | D | 0-0 |
| Anglicko - League 2 | 2020/09/19 14:00 | Tranmere v Cheltenham | L | 0-3 |
| Anglicko - League 2 | 2020/09/12 14:00 | Mansfield v Tranmere | D | 0-0 |
| Anglicko - EFL Trophy | 2020/09/08 18:00 | Port Vale v Tranmere | L | 4-3 |
Away History
| Anglicko - League 2 | 2020/10/17 16:30 | Leyton Orient v Grimsby | L | 2-3 |
| Anglicko - League 2 | 2020/10/13 18:00 | Walsall v Leyton Orient | L | 2-1 |
| Anglicko - League 2 | 2020/10/10 14:00 | Barrow v Leyton Orient | D | 1-1 |
| Anglicko - EFL Trophy | 2020/10/06 18:00 | Leyton Orient v AFC Wimbledon | W | 2-0 |
| Anglicko - League 2 | 2020/10/03 14:00 | Leyton Orient v Cheltenham | L | 0-2 |
| Anglicko - League 2 | 2020/09/19 14:00 | Leyton Orient v Mansfield | D | 2-2 |
| Anglicko - EFL Cup | 2020/09/15 18:45 | Leyton Orient v Plymouth | W | 3-2 |
| Anglicko - League 2 | 2020/09/12 14:00 | Oldham v Leyton Orient | W | 0-1 |
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