Stadium: Buccaneer Field Round: 1
Home Manager: Autry Denson Away Manager: Robert Prunty
| NCAAF | 2019/11/09 23:00 | Hampton v Charleston Southern | L | 20-27 |
| NCAAF | 2018/09/29 18:00 | Charleston Southern v Hampton | L | 48-14 |
| NCAAF | 2021/10/09 18:00 | Kennesaw State v Hampton | L | 34-15 |
| NCAAF | 2021/10/02 18:00 | Norfolk State v Hampton | L | 47-44 |
| NCAAF | 2021/09/18 16:00 | Hampton v Howard | W | 48-32 |
| NCAAF | 2021/09/11 23:00 | Hampton v Old Dominion | L | 7-47 |
| NCAAF | 2021/09/04 22:00 | Hampton v Virginia Union Panthers | W | 42-28 |
| NCAAF | 2019/11/23 17:00 | Hampton v Monmouth | L | 13-48 |
| NCAAF | 2019/11/16 18:00 | Hampton v Kennesaw State | L | 7-50 |
| NCAAF | 2019/11/09 23:00 | Hampton v Charleston Southern | L | 20-27 |
| NCAAF | 2021/10/09 19:00 | Charleston Southern v Robert Morris | L | 24-31 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | L | 28-31 |
| NCAAF | 2021/09/18 22:00 | Monmouth v Charleston Southern | L | 41-14 |
| NCAAF | 2021/09/11 18:00 | Charleston Southern v The Citadel | W | 38-21 |
| NCAAF | 2021/04/17 16:00 | Gardner Webb v Charleston Southern | W | 7-20 |
| NCAAF | 2021/04/10 16:00 | Robert Morris v Charleston Southern | W | 14-27 |
| NCAAF | 2021/03/27 17:00 | Charleston Southern v Monmouth | L | 17-35 |
| NCAAF | 2021/03/13 18:00 | Charleston Southern v Kennesaw State | L | 19-24 |