Stadium: Warren McGuirk Alumni Stadium Round: 1
Home Manager: Walt Bell Away Manager: Jim Fleming
| NCAAF | 2021/10/30 17:00 | Maine v Rhode Island | L | 45-24 |
| NCAAF | 2021/10/23 19:30 | Rhode Island v Villanova | L | 0-44 |
| NCAAF | 2021/10/16 20:00 | Rhode Island v Towson | L | 7-28 |
| NCAAF | 2021/10/09 17:00 | Delaware v Rhode Island | W | 15-22 |
| NCAAF | 2021/10/02 16:00 | Stony Brook v Rhode Island | W | 20-27 |
| NCAAF | 2021/09/18 16:30 | Rhode Island v Brown | W | 45-24 |
| NCAAF | 2021/09/11 23:00 | Rhode Island v Albany | W | 16-14 |
| NCAAF | 2021/09/04 22:00 | Bryant v Rhode Island | W | 21-45 |
| NCAAF | 2021/10/30 16:00 | Massachusetts v Libertay | L | 17-62 |
| NCAAF | 2021/10/23 16:00 | Massachusetts v Florida State | L | 3-59 |
| NCAAF | 2021/10/09 19:30 | Connecticut v Massachusetts | W | 13-27 |
| NCAAF | 2021/10/02 16:00 | Toledo v Massachusetts | L | 45-7 |
| NCAAF | 2021/09/25 17:00 | Massachusetts v Coastal Carolina | L | 3-53 |
| NCAAF | 2021/09/18 19:30 | Eastern Michigan v Massachusetts | L | 42-28 |
| NCAAF | 2021/09/11 19:30 | Boston College v Massachusetts | L | 45-28 |
| NCAAF | 2021/09/04 20:00 | Massachusetts v Pittsburgh | L | 7-51 |