| WTA - Štrasburg | 05/23 12:15 | 19 | Despina Papamichail v Maryna Zanevska | 6-4,2-6,5-7 | |
| WTA - Štrasburg | 05/22 12:00 | 14 | Angelina Gabueva v Despina Papamichail | 5-7,2-6 | |
| WTA - Štrasburg | 05/22 11:45 | 14 | Zarina Diyas v Despina Papamichail | Cancelled | |
| WTA - Štrasburg | 05/22 10:30 | - | [471] Angelina Gabueva v Despina Papamichail [273] | 5-7,2-5 | |
| ITF - W25 Platja D’Aro | 05/20 14:00 | 26 | Despina Papamichail v Carlota M Cirez | 4-6,2-6 | |
| ITF - W25 Platja D’Aro | 05/19 13:55 | 25 | [296] En Shuo Liang v Despina Papamichail [273] | 5-7,2-6 | |
| ITF - W100 Bonita Springs | 05/12 21:45 | 25 | [133] Irina Maria Bara v Despina Papamichail [270] | 6-3,6-1 | |
| ITF - W100 Bonita Springs | 05/11 14:00 | 54 | [211] Aleksandra Krunic v Despina Papamichail [270] | 6-3,5-7,12-14 | |
| ITF - W100 Bonita Springs | 05/10 19:00 | 54 | [289] Anna Danilina v Despina Papamichail [270] | 5-7,3-6 | |
| ITF - W25 Naples | 05/06 13:00 | 26 | [270] Despina Papamichail v Irina Fetecau [307] | 1-6,2-6 | |
| ITF - W25 Naples | 05/05 17:30 | 25 | [270] Despina Papamichail v Emiliana Arango [479] | 7-5,2-6,7-5 | |
| ITF - W60 Oeiras | 04/17 10:40 | 27 | [195] Georgina Garcia-Perez v Despina Papamichail [276] | 6-4,6-1 | |
| ITF - W60 Oeiras | 04/16 09:25 | 29 | [276] Despina Papamichail v Greet Minnen [118] | 6-4,6-0 | |
| ITF - W60 Oeiras | 04/14 14:45 | 25 | [213] Martina Di Giuseppe v Despina Papamichail [276] | 1-6,4-6 | |
| ITF - W60 Oeiras | 04/13 15:30 | 24 | [448] Sina Herrmann v Despina Papamichail [276] | 2-6,6-1,6-7 | |
| ITF - W25 Córdoba | 04/08 13:00 | 26 | Despina Papamichail v Panna Udvardy | 3-6,6-2,2-6 | |
| ITF - W25 Córdoba | 04/07 15:10 | 25 | [272] Andrea Lazaro Garcia v Despina Papamichail [275] | 4-6,5-7 | |
| ITF - W25 Villa Maria | 04/01 17:35 | 26 | [277] Susan Bandecchi v Despina Papamichail [278] | 6-0,7-6 | |
| ITF - W25 Villa Maria | 03/30 17:55 | 25 | [278] Despina Papamichail v Diana Marcinkevica [281] | 1-6,7-6,6-3 | |
| ITF - W25 Buenos Aires | 03/23 15:55 | 25 | [278] Despina Papamichail v Yuki Naito [189] | 6-1,1-6,4-6 | |
| ITF - W25 Newport Beach | 03/05 17:30 | 26 | [356] Beatriz Haddad Maia v Despina Papamichail [279] | 6-0,7-5 | |
| ITF - W25 Newport Beach | 03/03 22:00 | 25 | [267] Katherine Sebov v Despina Papamichail [279] | 4-6,7-6,3-6 | |
| ITF - W25 Boca Raton | 02/25 17:20 | 26 | [277] Despina Papamichail v Gabriela Talaba [213] | 6-4,3-6,3-6 | |
| ITF - W25 Boca Raton | 02/24 20:00 | 25 | [303] Ana Sofia Sanchez v Despina Papamichail [277] | 7-5,5-7,3-6 | |
| ITF - W25 Boca Raton | 02/24 19:30 | 25 | Anhelina Kalinina v Despina Papamichail | Cancelled | |
| ITF - W25 Boca Raton | 02/23 18:55 | 54 | [277] Despina Papamichail v Ana Sofia Sanchez [303] | 6-3,6-2 | |
| ITF - W25 Boca Raton | 02/22 15:00 | 54 | Despina Papamichail v Barbara Gatica | 7-6,6-3 | |
| ITF - W25 Orlando | 02/15 15:30 | 54 | Despina Papamichail v Lucrezia Stefanini | 2-6,3-6 | |
| ITF - W60 Rome, GA | 01/28 20:10 | 26 | [331] Irene Burillo Escorihuela v Despina Papamichail [277] | 6-2,6-1 | |
| ITF - W60 Rome, GA | 01/27 16:50 | 25 | [277] Despina Papamichail v Francesca Di Lorenzo [143] | 6-3,6-1 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.