Stadium: Roy Kidd Stadium Round: 1
Home Manager: Walt Wells Away Manager: Tom Matukewicz
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri St | L | 28-23 |
| NCAAF | 2019/11/09 19:00 | Eastern Kentucky v SE Missouri St | W | 31-38 |
| NCAAF | 2018/09/22 20:00 | SE Missouri St v Eastern Kentucky | L | 14-23 |
| NCAAF | 2017/09/30 23:00 | SE Missouri St v Eastern Kentucky | W | 29-10 |
| NCAAF | 2023/09/16 23:00 | SO Illinois v SE Missouri St | L | 26-25 |
| NCAAF | 2023/09/09 23:00 | Lindenwood v SE Missouri St | W | 7-45 |
| NCAAF | 2023/09/02 23:00 | SE Missouri St v Kansas State | L | 0-45 |
| NCAAF | 2022/11/27 03:00 | SE Missouri St v Montana | L | 24-34 |
| NCAAF | 2022/11/19 19:00 | Murray State v SE Missouri St | W | 22-52 |
| NCAAF | 2022/11/12 20:00 | SE Missouri St v Eastern Illinois | W | 31-7 |
| NCAAF | 2022/11/05 22:00 | SE Missouri St v Tennessee State | W | 42-0 |
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri St | L | 28-23 |
| NCAAF | 2023/09/16 22:00 | Western Carolina v Eastern Kentucky | L | 27-24 |
| NCAAF | 2023/09/09 19:00 | Eastern Kentucky v Kentucky | L | 17-28 |
| NCAAF | 2023/09/02 19:30 | Eastern Kentucky v Cincinnati | L | 13-66 |
| NCAAF | 2022/11/26 22:00 | Gardner Webb v Eastern Kentucky | L | 52-41 |
| NCAAF | 2022/11/19 20:00 | Kennesaw State v Eastern Kentucky | W | 38-45 |
| NCAAF | 2022/11/12 19:00 | Eastern Kentucky v Jacksonville State | L | 17-42 |
| NCAAF | 2022/11/05 21:00 | Central Arkansas v Eastern Kentucky | W | 14-42 |
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri St | W | 28-23 |