Stadium: Roy Kidd Stadium Round: 1
Home Manager: Walt Wells Away Manager: Tom Matukewicz
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri St | L | 28-23 |
| NCAAF | 2019/11/09 19:00 | Eastern Kentucky v SE Missouri St | W | 31-38 |
| NCAAF | 2018/09/22 20:00 | SE Missouri St v Eastern Kentucky | L | 14-23 |
| NCAAF | 2017/09/30 23:00 | SE Missouri St v Eastern Kentucky | W | 29-10 |